<i>In vitro</i> evaluation of intestinal absorption of tiliroside from <i>Edgeworthia gardneri</i> (Wall.) Meisn.

Although Edgeworthia gardneri (Wall.) Meisn and its main component tiliroside (TIL) show good bioactivity, intestinal absorption data supporting low bioavailability have not been reported.The evaluation results of three models in vitro vivo indicated that the Ussing chamber model were basically consistent with experiments. It was thus applied to investigate characteristics TIL across various regions interaction between adenosine triphosphate (ATP)-binding cassette family proteins (ABC) including, P-glycoprotein (P-gp), multidrug resistance-associated protein 2 (MRP2), breast cancer resistance (BCRP).The bi-directional transport showed ileum had higher apparent permeability coefficient (Papp) than duodenum jejunum, suggesting best ileum.In presence MRP2 inhibitor, from water extracts E. (WAE) improved, indicating other P-gp BCRP affected might be responsible for bioavailability. This study laid foundation enhancing highlighted influences efflux transporters on